Please guide, Institute of Organic Chemistry and Biochemistry of the CAS, 1. Most native ESI-MS studies employ neutral aqueous ammonium acetate solutions. Acetate Buffer Calculator. The most common way to do this is to weigh out the ammonium acetate as described above (0.308 g), then use … Ammonium acetate is sufficiently volatile for LC-MS use, but we are left with the 2.0